Auítzotl (sometimes rendered as Ahuitzotl) was the Aztec ruler of the city of Tenochtitlán. He took power as Tlatoani in 1486, after his predecessor Tízoc was poisoned. Perhaps the greatest known military leader of Pre-Columbian Mesoamerica, he began his reign by suppressing a Huastec rebellion, and then swiftly more than doubled the size of lands under Aztec dominance. He conquered the Mixtec, Zapotec, and other peoples from Mexico's Pacific coast down to the western part of Guatemala. Auitzotl also supervised a major rebuilding of Tenochtitlán on a grander scale.

Auitzotl was succeeded in 1502 by Moctezuma II (the famous "Montezuma" humiliated by Cortés).